Polar bodies are efficient donors for reconstruction of human embryos for potential mitochondrial replacement therapy

Keliang Wu; Cuiqing Zhong; Tailai Chen; Xiaoyu Zhang; Wenrong Tao; Jingye Zhang; Hongchang Li; Han Zhao; Jinsong Li; Zi-Jiang Chen

doi:10.1038/cr.2017.67

Polar bodies are efficient donors for reconstruction of human embryos for potential mitochondrial replacement therapy

Cell Res. 2017 Aug;27(8):1069-1072. doi: 10.1038/cr.2017.67. Epub 2017 May 12.

Authors

Keliang Wu^{1

2

3}, Cuiqing Zhong^{1

2

3

4

5

6}, Tailai Chen^{1

2

3}, Xiaoyu Zhang⁶, Wenrong Tao^{1

2

3}, Jingye Zhang^{1

2

3}, Hongchang Li^{1

2

3}, Han Zhao^{1

2

3}, Jinsong Li^{6

7}, Zi-Jiang Chen^{1

2

3

4

5}

Affiliations

¹ Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250001, China.
² National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, Shandong 250001, China.
³ The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, Shandong 250001, China.
⁴ Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, China.
⁵ Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200135, China.
⁶ State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences &University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
⁷ School of Life Science and Technology, ShanghaiTech University, 100 Haike Road, Shanghai 201210, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

DNA, Mitochondrial / metabolism
Embryo, Mammalian / metabolism*
Embryonic Stem Cells / metabolism
Humans
Mitochondrial Replacement Therapy*
Oocytes / metabolism
Polar Bodies / metabolism*
Zygote / metabolism

Substances

DNA, Mitochondrial