Are sensitized patients better off with a desensitization transplant or waiting on dialysis?

Philip A Clayton; P Toby Coates

doi:10.1016/j.kint.2017.04.004

Are sensitized patients better off with a desensitization transplant or waiting on dialysis?

Kidney Int. 2017 Jun;91(6):1266-1268. doi: 10.1016/j.kint.2017.04.004.

Authors

Philip A Clayton¹, P Toby Coates²

Affiliations

¹ Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, Adelaide, South Australia, Australia; Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
² Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia. Electronic address: [email protected].

PMID: 28501297
DOI: 10.1016/j.kint.2017.04.004

Abstract

Sensitization to human leukocyte antigens (HLAs) remains one of the major clinical challenges for successful kidney transplantation. Two large observational studies have recently addressed the question of whether individuals are better off with a desensitization treatment followed by HLA-incompatible living donor transplantation or waiting on the deceased donor kidney transplant list for a compatible transplant. The conflicting results of these 2 studies largely reflect differences in the study design and study population, leaving clinicians to make decisions about desensitization based largely on local expertise and anticipated waiting times for a compatible deceased donor transplant.

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MeSH terms

Desensitization, Immunologic
Humans
Kidney Failure, Chronic*
Kidney Transplantation
Living Donors
Renal Dialysis*
Waiting Lists