Tau at the Crossroads between Neurotoxicity and Neuroprotection

Sarah L DeVos; Bradley T Hyman

doi:10.1016/j.neuron.2017.05.001

Tau at the Crossroads between Neurotoxicity and Neuroprotection

Neuron. 2017 May 17;94(4):703-704. doi: 10.1016/j.neuron.2017.05.001.

Authors

Sarah L DeVos¹, Bradley T Hyman²

Affiliations

¹ Massachusetts General Hospital, Harvard Medical School, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA.
² Massachusetts General Hospital, Harvard Medical School, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA. Electronic address: [email protected].

PMID: 28521124
DOI: 10.1016/j.neuron.2017.05.001

Abstract

In contrast to the idea that tau phosphorylation is toxic, Ittner et al. (2016) recently showed that specific tau phosphorylation is neuroprotective, phenocopying tau ablation (DeVos et al., 2017), thus highlighting the complex tau biology that underlies neurotoxicity and neuroprotection.

Keywords: Alzheimer’s disease; amyloid-beta; antisense oligonucleotide; kinase; knockdown; neuroprotective; p38 gamma; phosphorylation; tau.

MeSH terms

Alzheimer Disease
Amyloid beta-Peptides*
Neuroprotection
Phosphorylation
tau Proteins*

Substances

Amyloid beta-Peptides
tau Proteins