Stretch-activated potassium currents in the heart: Focus on TREK-1 and arrhythmias

Niels Decher; Aytug K Kiper; Susanne Rinné

doi:10.1016/j.pbiomolbio.2017.05.005

Stretch-activated potassium currents in the heart: Focus on TREK-1 and arrhythmias

Prog Biophys Mol Biol. 2017 Nov;130(Pt B):223-232. doi: 10.1016/j.pbiomolbio.2017.05.005. Epub 2017 May 16.

Authors

Niels Decher¹, Aytug K Kiper², Susanne Rinné²

Affiliations

¹ Institute for Physiology and Pathophysiology, AG Vegetative Physiology, Deutschhausstrasse 1-2, 35037 Marburg, Germany. Electronic address: [email protected].
² Institute for Physiology and Pathophysiology, AG Vegetative Physiology, Deutschhausstrasse 1-2, 35037 Marburg, Germany.

PMID: 28526352
DOI: 10.1016/j.pbiomolbio.2017.05.005

Abstract

This review focuses on the role and the molecular candidates of the cardiac stretch-activated potassium current (SAK). The functional properties of the two-pore domain potassium (K_2P) channel TREK-1, a major candidate for the cardiac SAK, are analyzed and the molecular mechanism of stretch-activation in K_2P potassium channels is discussed. Furthermore, the functional modulation of TREK-1 by different cardiac interaction partners, as well as evidence for the functional role of the stretch-dependent TREK-1 and its putative subunits in the heart is reviewed. In addition, we summarize the recent evidence that TREK-1 is involved in the pathogenesis of human cardiac arrhythmias.

Keywords: K(2P) channel; MEF; SAC; SAK; Stretch-activated ion channel; TREK-1.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Arrhythmias, Cardiac / metabolism*
Arrhythmias, Cardiac / physiopathology
Biomechanical Phenomena
Humans
Mechanical Phenomena*
Myocardium / metabolism*
Potassium / metabolism*
Potassium Channels, Tandem Pore Domain / metabolism*

Substances

Potassium Channels, Tandem Pore Domain
potassium channel protein TREK-1
Potassium