Identifying artemisinin resistance from parasite clearance half-life data with a simple Shiny web application

Sai Thein Than Tun; Yoel Lubell; Arjen M Dondorp; Tom Fieldman; Kyaw Myo Tun; Olivier Celhay; Xin Hui Chan; Sompob Saralamba; Lisa J White

doi:10.1371/journal.pone.0177840

Identifying artemisinin resistance from parasite clearance half-life data with a simple Shiny web application

PLoS One. 2017 May 22;12(5):e0177840. doi: 10.1371/journal.pone.0177840. eCollection 2017.

Authors

Sai Thein Than Tun¹, Yoel Lubell^{1

2}, Arjen M Dondorp^{1

2}, Tom Fieldman³, Kyaw Myo Tun⁴, Olivier Celhay¹, Xin Hui Chan^{1

2}, Sompob Saralamba¹, Lisa J White^{1

2}

Affiliations

¹ Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
² Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
³ School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
⁴ Defence Services Medical Academy, Yangon, Myanmar.

Abstract

The emergence of artemisinin-resistant Plasmodium falciparum malaria is a major threat to malaria elimination. New tools for supporting the surveillance of artemisinin resistance are critical for current and future malaria control and elimination strategies. We have developed an open-access, user-friendly, web-based tool to analyse parasite clearance half-life data of P. falciparum infected patients after treatment with artemisinin derivatives, so that resistance to artemisinin can be identified. The tool can be accessed at bit.ly/id_artemisinin_resistance.

MeSH terms

Animals
Antimalarials / administration & dosage*
Antimalarials / therapeutic use
Artemisinins / administration & dosage*
Artemisinins / therapeutic use
Databases, Factual
Drug Resistance*
Half-Life
Humans
Malaria, Falciparum / drug therapy*
Open Access Publishing
Plasmodium falciparum / drug effects
Web Browser

Substances

Antimalarials
Artemisinins

Grants and funding

This work was funded by Bill and Melinda Gates Foundation Investment number OPP1110500 awarded to LJW. It was also a part of the Wellcome-Trust Major Overseas Programme in SE Asia (grant number 106698/Z/14/Z). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.