Unfolding the Folding Problem of the Cerebral Cortex: Movin' and Groovin'

Yasuhiro Itoh; Alexandros Poulopoulos; Jeffrey D Macklis

doi:10.1016/j.devcel.2017.05.011

Unfolding the Folding Problem of the Cerebral Cortex: Movin' and Groovin'

Dev Cell. 2017 May 22;41(4):332-334. doi: 10.1016/j.devcel.2017.05.011.

Authors

Yasuhiro Itoh¹, Alexandros Poulopoulos², Jeffrey D Macklis³

Affiliations

¹ Department of Stem Cell and Regenerative Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
² Department of Pharmacology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
³ Department of Stem Cell and Regenerative Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA. Electronic address: [email protected].

Abstract

The development of reproducible folding in the gyrencephalic cerebral cortex is a topic of great interest to neuroscientists. In a recent paper in Cell, del Toro et al. (2017) show that changing the adhesive properties of neurons in the normally lissencephalic mouse cortex leads to the formation of stereotyped folding.

Unfolding the Folding Problem of the Cerebral Cortex: Movin' and Groovin'

Authors

Affiliations

Abstract

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