Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline

Alice Chen; Kenneth P Smith; Betsy A Whitfield; Paola C Zucchi; Todd M Lasco; Tiffany E Bias; James E Kirby; Elizabeth B Hirsch

doi:10.1016/j.diagmicrobio.2017.05.004

Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline

Diagn Microbiol Infect Dis. 2017 Aug;88(4):365-367. doi: 10.1016/j.diagmicrobio.2017.05.004. Epub 2017 May 11.

Authors

Alice Chen¹, Kenneth P Smith², Betsy A Whitfield¹, Paola C Zucchi¹, Todd M Lasco³, Tiffany E Bias⁴, James E Kirby⁵, Elizabeth B Hirsch⁶

Affiliations

¹ Northeastern University, Boston, MA, USA.
² Beth Israel Deaconess Medical Center, Boston, MA, USA.
³ CHI Baylor St. Luke's Medical Center, Houston, TX, USA.
⁴ Hahnemann University Hospital, Philadelphia, PA, USA; Drexel University College of Medicine, Philadelphia, PA, USA.
⁵ Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
⁶ Northeastern University, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: [email protected].

PMID: 28535946
DOI: 10.1016/j.diagmicrobio.2017.05.004

Abstract

We examined the in vitro activity of minocycline against 103 Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae isolates and found approximately half had susceptible (26%) or intermediate (26%) MICs. For a subset of 35 isolates, susceptibility was highest to tigecycline (71% FDA vs. 20% EUCAST) followed by minocycline (14%) and then doxycycline (6%).

Keywords: Extended-spectrum beta-lactamase; KPC; Multidrug resistance; Resistant; Tetracycline.

MeSH terms

Anti-Bacterial Agents / therapeutic use
Bacterial Proteins / metabolism*
Carbapenem-Resistant Enterobacteriaceae / drug effects*
Carbapenem-Resistant Enterobacteriaceae / metabolism
Doxycycline / therapeutic use*
Enterobacteriaceae Infections / drug therapy*
Enterobacteriaceae Infections / microbiology
Humans
Klebsiella pneumoniae / drug effects*
Klebsiella pneumoniae / metabolism
Microbial Sensitivity Tests
Minocycline / analogs & derivatives*
Minocycline / therapeutic use*
Tigecycline
beta-Lactamases / metabolism*

Substances

Anti-Bacterial Agents
Bacterial Proteins
Tigecycline
beta-Lactamases
carbapenemase
Minocycline
Doxycycline