Guideline for PET/CT imaging of neuroendocrine neoplasms with 68Ga-DOTA-conjugated somatostatin receptor targeting peptides and 18F-DOPA

Murat Fani Bozkurt; Irene Virgolini; Sona Balogova; Mohsen Beheshti; Domenico Rubello; Clemens Decristoforo; Valentina Ambrosini; Andreas Kjaer; Roberto Delgado-Bolton; Jolanta Kunikowska; Wim J G Oyen; Arturo Chiti; Francesco Giammarile; Anders Sundin; Stefano Fanti

doi:10.1007/s00259-017-3728-y

Guideline for PET/CT imaging of neuroendocrine neoplasms with ⁶⁸Ga-DOTA-conjugated somatostatin receptor targeting peptides and ¹⁸F-DOPA

Eur J Nucl Med Mol Imaging. 2017 Aug;44(9):1588-1601. doi: 10.1007/s00259-017-3728-y. Epub 2017 May 25.

Authors

Murat Fani Bozkurt¹, Irene Virgolini², Sona Balogova^{3

4}, Mohsen Beheshti^{5

6}, Domenico Rubello⁷, Clemens Decristoforo², Valentina Ambrosini⁸, Andreas Kjaer⁹, Roberto Delgado-Bolton¹⁰, Jolanta Kunikowska¹¹, Wim J G Oyen¹², Arturo Chiti¹³, Francesco Giammarile¹⁴, Anders Sundin, Stefano Fanti⁸

Affiliations

¹ Hacettepe University Faculty of Medicine Department of Nuclear Medicine, Ankara, Turkey. [email protected].
² Department of Nuclear Medicine, Medical University Innsbruck, Innsbruck, Austria.
³ Department of Nuclear Medicine, Comenius University and St. Elisabeth Oncology Institute, Bratislava, Slovakia.
⁴ Department of Nuclear Medicine, Tenon Hospital AP-HP & Université Pierre et Marie Curie, Paris, France.
⁵ PET-CT Center, Department of Nuclear Medicine & Endocrinology, St. Vincent's Hospital, Linz, Austria.
⁶ Department of Nuclear Medicine, Paracelsus Medical University, Salzburg, Austria.
⁷ Department of Nuclear Medicine, PET Center and Medical Physics and Radiology, Santa Maria della Misericordia Hospital, Rovigo, Italy.
⁸ Department of Experimental, Diagnostic and Specialty Medicine-DIMES, University of Bologna, Bologna, Italy.
⁹ Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, National University Hospital & University of Copenhagen, Copenhagen, Denmark.
¹⁰ Department of Diagnostic Imaging (Radiology) and Nuclear Medicine, San Pedro Hospital and Centre for Biomedical Research of La Rioja (CIBIR), Logroño, Spain. [email protected].
¹¹ Nuclear Medicine, Medical University of Warsaw, Warsaw, Poland.
¹² Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
¹³ Nuclear Medicine Department, Humanitas University, Rozzano, MI, Italy.
¹⁴ Nuclear Medicine, University of Lyon, Lyon, France.

PMID: 28547177
DOI: 10.1007/s00259-017-3728-y

Abstract

Purpose & methods: Neuroendocrine neoplasms are a heterogenous group of tumours, for which nuclear medicine plays an important role in the diagnostic work-up as well as in the targeted therapeutic options. This guideline is aimed to assist nuclear medicine physicians in recommending, performing, reporting and interpreting the results of somatostatin receptor (SSTR) PET/CT imaging using ⁶⁸Ga-DOTA-conjugated peptides, as well as ¹⁸F-DOPA imaging for various neuroendocrine neoplasms.

Results & conclusion: The previous procedural guideline by EANM regarding the use PET/CT tumour imaging with ⁶⁸Ga-conjugated peptides has been revised and updated with the relevant and recent literature in the field with contribution of distinguished experts.

Keywords: 18F–DOPA; 18F–FDG; 68Ga-DOTANOC; 68Ga-DOTATATE; 68Ga-DOTATOC; Foregut-NET; Hindgut-NET; Hyperinsulism in infants; Midgut-NET; Neuroendocrine neoplasms; Neuroendocrine tumours; Paraganglioma; Pet/Ct; Pheochromoacytoma; Thyroid medullary cancer.

MeSH terms

Dihydroxyphenylalanine / analogs & derivatives*
Gallium Radioisotopes*
Heterocyclic Compounds, 1-Ring / chemistry*
Humans
Image Interpretation, Computer-Assisted
Neuroendocrine Tumors / diagnostic imaging*
Peptides / chemistry
Peptides / metabolism*
Peptides / pharmacokinetics
Positron Emission Tomography Computed Tomography / methods*
Practice Guidelines as Topic
Quality Control
Receptors, Somatostatin / metabolism*
Tissue Distribution

Substances

Gallium Radioisotopes
Heterocyclic Compounds, 1-Ring
Peptides
Receptors, Somatostatin
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
fluorodopa F 18
Dihydroxyphenylalanine
Gallium-68