Myasthenia gravis after allogeneic bone marrow transplantation: A case report and literature review

Yutaka Tsutsumi; Takashi Kamiishi; Ryo Kikuchi; Shinichi Ito; Satomi Matsuoka; Takanori Teshima

doi:10.1016/j.hemonc.2017.04.001

Myasthenia gravis after allogeneic bone marrow transplantation: A case report and literature review

Hematol Oncol Stem Cell Ther. 2019 Jun;12(2):110-114. doi: 10.1016/j.hemonc.2017.04.001. Epub 2017 May 18.

Authors

Yutaka Tsutsumi¹, Takashi Kamiishi², Ryo Kikuchi², Shinichi Ito², Satomi Matsuoka², Takanori Teshima³

Affiliations

¹ Department of Hematology, Hakodate Municipal Hospital, Hakodate, Japan. Electronic address: [email protected].
² Department of Hematology, Hakodate Municipal Hospital, Hakodate, Japan.
³ Department of Hematology, Hokkaido Graduate School of Medicine, Sapporo, Japan.

PMID: 28549768
DOI: 10.1016/j.hemonc.2017.04.001

Abstract

A 52-year-old man with acute myeloid leukemia underwent allogeneic hematopoietic stem cell transplantation and developed extensive chronic graft-versus-host disease and myasthenia gravis (MG), which became involved with oculobulbar and proximal upper and lower limb weakness in 677days. In the literature, we identified 24 cases where MG developed after allo-SCT. Graft-versus-host disease development and male recipients of female donors might be prone to the development of posttransplant MG (odds ratio, 3.75).

Keywords: Acetylcholine receptor antibody; Allogeneic stem cell transplantation; Chronic GVHD; Myasthenia gravis.

Publication types

Case Reports
Review

MeSH terms

Allografts
Bone Marrow Transplantation*
Chronic Disease
Graft vs Host Disease* / etiology
Graft vs Host Disease* / metabolism
Graft vs Host Disease* / pathology
Humans
Leukemia, Myeloid, Acute* / metabolism
Leukemia, Myeloid, Acute* / pathology
Leukemia, Myeloid, Acute* / therapy
Male
Middle Aged
Myasthenia Gravis* / etiology
Myasthenia Gravis* / metabolism
Myasthenia Gravis* / pathology