Abstract
The immunogenicity of the four sequential polymers of alpha-L-amino acids referred to below was studied in inbred strains of mice. The responses were linked to the H-2 haplotype, and the Ir genes controlling the responses were mapped to the IA region. The responses were restricted to two haplotypes as follows: (Ala-Tyr-Glu-Gly)n and (Ala-Glu-Tyr-Gly)n - H-2k; (Glu-Ala-Tyr-Gly)n - H-2b; (Glu-Tyr-Ala-Gly)n - H-2k and b. The absence of reciprocal crossreactions among all of these polymers, plus the sequential polymers (Tyr-Ala-Glu-Gly)n and (Tyr-Glu-Ala-Gly)n at both the antibody and T-cell levels, indicated that each of these six polymers was indeed structurally unique.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Antibody Formation
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Genetic Linkage
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Haplotypes
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Histocompatibility Antigens Class II / genetics*
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Histocompatibility Antigens Class II / immunology
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Major Histocompatibility Complex*
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Mice
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Mice, Inbred Strains / genetics
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Mice, Inbred Strains / immunology*
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Molecular Sequence Data
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Peptides / immunology*
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Receptors, Antigen, T-Cell / genetics*
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Receptors, Antigen, T-Cell / isolation & purification
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T-Lymphocytes / immunology
Substances
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Histocompatibility Antigens Class II
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Peptides
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Receptors, Antigen, T-Cell
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poly(glutamyl-tyrosyl-alanyl-glycine)
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poly(alanyl-glutamyl-tyrosyl-glycine)
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poly(alanyl-tyrosyl-glutamyl-glycine)
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poly(glutamyl-alanyl-tyrosyl-glycine)