Spiroannulation of Oxindoles via Aryne and Alkyne Incorporation: Substituent-Diverted, Transition-Metal-Free, One-Pot Access to Spirooxindoles

Org Lett. 2017 Jun 16;19(12):3119-3122. doi: 10.1021/acs.orglett.7b01233. Epub 2017 Jun 2.

Abstract

A "product control via substrate design" strategy has been conceptualized and implemented to harness the potential of aryne and activated alkyne insertions into oxindoles to readily and efficiently furnish pharmacophoric indano- and cyclopentannulated spirooxindole scaffolds in an operationally straightforward, one-pot, transition-metal-free protocol.

Publication types

  • Research Support, Non-U.S. Gov't