Direct Gallbladder Indocyanine Green Injection Fluorescence Cholangiography During Laparoscopic Cholecystectomy

J Laparoendosc Adv Surg Tech A. 2017 Oct;27(10):1069-1073. doi: 10.1089/lap.2017.0070. Epub 2017 Jun 2.

Abstract

Background: Intravenous injection of indocyanine green (ICG) is used to illuminate extrahepatic biliary anatomy. Fluorescence of biliary structures may lower surgical complications that can arise due to inadvertent injury to the common bile duct. We describe a method of injecting ICG directly into the gallbladder to define the cystic duct and common bile duct anatomy.

Materials and methods: A standard laparoscopic cholecystectomy was performed using a laparoscope with near-infrared imaging capability. Before dissection, the gallbladder was punctured with a cholangiogram catheter or a pigtail catheter to aspirate the bile within the gallbladder. The aspirated bile is mixed with ICG solution, which is reinjected into the gallbladder to fluoresce the gallbladder, cystic duct, and common bile duct structures.

Results: Eleven patients underwent direct gallbladder ICG injection for fluorescence cholangiography during cholecystectomy. Direct gallbladder ICG injection clearly defined the extrahepatic biliary anatomy, including the cystic duct-common bile duct junction, by fluorescence. In addition, the dissection plane between the gallbladder and the liver is highlighted with the gallbladder ICG fluorescence.

Conclusions: Direct gallbladder ICG injection provides immediate visualization of extrahepatic biliary structures and clarifies the dissection plane between the gallbladder and the liver bed.

Keywords: cholecystectomy; common bile duct injury; direct injection; fluorescence cholangiography; indocyanine green.

MeSH terms

  • Adult
  • Aged
  • Biliary Tract / diagnostic imaging*
  • Cholangiography / methods*
  • Cholecystectomy
  • Cholecystectomy, Laparoscopic / methods*
  • Coloring Agents
  • Contrast Media
  • Female
  • Fluorescence
  • Gallbladder / diagnostic imaging
  • Humans
  • Indocyanine Green / administration & dosage*
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Young Adult

Substances

  • Coloring Agents
  • Contrast Media
  • Indocyanine Green