Biologic Options for Articular Cartilage Wear (Platelet-Rich Plasma, Stem Cells, Bone Marrow Aspirate Concentrate)

Clin Sports Med. 2017 Jul;36(3):457-468. doi: 10.1016/j.csm.2017.02.004. Epub 2017 Apr 1.

Abstract

Biological treatments for articular cartilage repair have gained in popularity in the past decade. Advantages of these therapies include minimal invasiveness, improved healing time, and faster recovery. Biological therapies for cartilage repair include platelet-rich plasma, bone marrow aspirate concentrate, and cell-based therapies. These methods have the added benefit of containing growth factors and/or stem cells that aid in recovery and regeneration. The purpose of this article is to review the current cartilage treatment options and the existing literature on outcomes, complications, and safety profile of these products for use in the knee and hip joints.

Keywords: Articular cartilage; Bone marrow aspirate concentrate; Platelet-rich plasma; Stem cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Products / adverse effects
  • Biological Products / therapeutic use*
  • Bone Marrow Transplantation / adverse effects
  • Cartilage Diseases / therapy*
  • Cartilage, Articular*
  • Humans
  • Osteoarthritis, Hip / therapy*
  • Osteoarthritis, Knee / therapy*
  • Platelet-Rich Plasma*
  • Stem Cell Transplantation* / adverse effects

Substances

  • Biological Products