Effect of Motherwort total alkaloids on the prostate hyperplasia mice model of pathological changes of related tissue morphology induced by the fetal urogenital sinus implants

Mingsan Miao; Shuo Tian; Ming Bai; Liling Xiang; Jianlian Gao

doi:10.1016/j.jsps.2017.04.030

Effect of Motherwort total alkaloids on the prostate hyperplasia mice model of pathological changes of related tissue morphology induced by the fetal urogenital sinus implants

Saudi Pharm J. 2017 May;25(4):601-606. doi: 10.1016/j.jsps.2017.04.030. Epub 2017 May 7.

Authors

Mingsan Miao¹, Shuo Tian¹, Ming Bai¹, Liling Xiang¹, Jianlian Gao¹

Affiliation

¹ Departments of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450000, Henan, China.

Abstract

Aim: The research was to study the effect of Motherwort total alkaloids on the prostate hyperplasia mice model of pathological changes of related tissue morphology.

Results: Compared with the model group(MG), Motherwort total alkaloid high, medium dose group(HD, MD) could significantly reduced the pathological changes of the prostate (P < 0.01); Finasteride(FG) and Motherwort total alkaloid low dose group(LD) could significantly reduce the pathological changes of the prostate (P < 0.05); Longbishu capsules(LG), Finasteride, Motherwort total alkaloid medium dose group could significantly reduce the pathological changes of the kidney (P < 0.01); Motherwort total alkaloid low dose group could significantly reduce the pathological changes of the kidney (P < 0.05); Motherwort total alkaloids could improve the pathological changes of the thymus and spleen.

Conclusion: Motherwort total alkaloid can improve the pathological changes of prostatic hyperplasia in mice.

Keywords: Kidney; Mice model; Motherwort total alkaloids; Prostate; Prostate hyperplasia; Spleen; Thymus.