HUGIn: Hi-C Unifying Genomic Interrogator

Bioinformatics. 2017 Dec 1;33(23):3793-3795. doi: 10.1093/bioinformatics/btx359.

Abstract

Motivation: High throughput chromatin conformation capture (3C) technologies, such as Hi-C and ChIA-PET, have the potential to elucidate the functional roles of non-coding variants. However, most of published genome-wide unbiased chromatin organization studies have used cultured cell lines, limiting their generalizability.

Results: We developed a web browser, HUGIn, to visualize Hi-C data generated from 21 human primary tissues and cell lines. HUGIn enables assessment of chromatin contacts both constitutive across and specific to tissue(s) and/or cell line(s) at any genomic loci, including GWAS SNPs, eQTLs and cis-regulatory elements, facilitating the understanding of both GWAS and eQTL results and functional genomics data.

Availability and implementation: HUGIn is available at http://yunliweb.its.unc.edu/HUGIn.

Contact: [email protected] or [email protected].

Supplementary information: Supplementary data are available at Bioinformatics online.

MeSH terms

  • Cell Line
  • Chromatin / metabolism
  • Chromatin / ultrastructure*
  • Genome-Wide Association Study / methods*
  • Genomics / methods*
  • Humans
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci*
  • Regulatory Sequences, Nucleic Acid*
  • Software*

Substances

  • Chromatin