For Certain, SIRT4 Activities!

Surinder Kumar; David B Lombard

doi:10.1016/j.tibs.2017.05.008

For Certain, SIRT4 Activities!

Trends Biochem Sci. 2017 Jul;42(7):499-501. doi: 10.1016/j.tibs.2017.05.008. Epub 2017 Jun 3.

Authors

Surinder Kumar¹, David B Lombard²

Affiliations

¹ Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
² Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: [email protected].

Abstract

Despite the fact that SIRT4 regulates important biological processes, its primary enzymatic activity has remained ambiguous. A recent study by Anderson, Huynh et al. has uncovered deacylase activities of SIRT4 towards newly described lysine modifications derived from reactive acyl-CoAs generated in leucine catabolism.

Keywords: HMGylation; MGcylation; MGylation; SIRT4; Sirtuins.

Publication types

Comment

MeSH terms

Lysine
Mitochondrial Proteins*
Sirtuins*

Substances

Mitochondrial Proteins
Sirtuins
Lysine

Abstract

Publication types

MeSH terms

Substances

Grants and funding