Alcohol Septal Ablation to Reduce Heart Failure

Interv Cardiol Clin. 2017 Jul;6(3):445-452. doi: 10.1016/j.iccl.2017.03.012. Epub 2017 Apr 21.

Abstract

Hypertrophic cardiomyopathy is a commonly encountered inheritable cardiac disorder with variable phenotypic expression. Although most patients will have no or mild symptoms, 10% will develop heart failure symptoms refractory to medical management. This article discusses the mechanisms through which hypertrophic cardiomyopathy induces heart failure and how alcohol septal ablation can reverse each of these mechanisms to lead to clinical improvement.

Keywords: Alcohol septal ablation; Heart failure; Hypertrophic cardiomyopathy.

Publication types

  • Review

MeSH terms

  • Ablation Techniques / methods*
  • Disease Progression
  • Ethanol / pharmacology*
  • Heart Failure / therapy*
  • Heart Septum / drug effects*
  • Humans

Substances

  • Ethanol