Laryngeal mask (LM) and inhaled anesthesia combination is often deemed unsuitable. Actually the evolution of surgical procedures towards minimal invasiveness, the search of improved productivity, and the contemporary need for patient safety and faster recovery, push the anesthetists to get interested in their use in the daily practice. An Expert Panel composed by anesthetists coming from university and tertiary hospitals undertook to write an experts' opinion on the correct management of LM and desflurane in adult patients, with a view to issuing a simple operative protocol for their combined intraoperative usage. Main operative steps have been defined, which, if appropriately implemented, would successfully achieve safety objectives. Two aspects are considered crucial, first the educational role of Universities and Medical Schools to structure a systematic approach to the theoretical and practical teaching of the use of LM with desflurane; second an appropriate training for improving the skills in the use of LM also for more complicated patients.