On the challenges of detecting whole Staphylococcus aureus cells with biosensors

J Appl Microbiol. 2017 Nov;123(5):1056-1067. doi: 10.1111/jam.13510. Epub 2017 Aug 13.

Abstract

Due to the increasing number of nosocomial infections and multidrug-resistant bacterial strains, Staphylococcus aureus is now a major worldwide concern. Rapid detection and characterization of this bacterium has become an important issue for biomedical applications. Biosensors are increasingly appearing as low-cost, easy-to-operate and fast alternatives for rapid detection. In this review, we will introduce the main characteristics of S. aureus and will focus on the interest of biosensors for a faster detection of whole S. aureus cells. In particular, we will review the most promising strategies in the choice of ligand for the design of selective and efficient biosensors. Their specific characteristics as well as their advantages and/or disadvantages will also be commented.

Keywords: biosensors; diagnosis; nosocomial infection; rapid detection; staphylococci.

Publication types

  • Review

MeSH terms

  • Biosensing Techniques / economics
  • Biosensing Techniques / methods*
  • Cross Infection / diagnosis
  • Cross Infection / microbiology*
  • Humans
  • Staphylococcal Infections / diagnosis
  • Staphylococcal Infections / microbiology*
  • Staphylococcus aureus / genetics
  • Staphylococcus aureus / isolation & purification*