Multiple functions of protein phosphatases in receptor tyrosine kinase signaling revealed by interactome analysis

Zhong Yao; Igor Stagljar

doi:10.1080/23723556.2017.1297101

Multiple functions of protein phosphatases in receptor tyrosine kinase signaling revealed by interactome analysis

Mol Cell Oncol. 2017 Feb 26;4(3):e1297101. doi: 10.1080/23723556.2017.1297101. eCollection 2017.

Authors

Zhong Yao¹, Igor Stagljar^{1

2

3}

Affiliations

¹ Donnelly Centre, University of Toronto, Toronto, ON, Canada.
² Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
³ Department of Biochemistry, University of Toronto, Toronto, ON, Canada.

Abstract

To obtain a global picture of how protein phosphatases are involved in receptor tyrosine kinase (RTK) signaling, we mapped the RTK-phosphatase interactome. Analyses of selected interactions revealed detailed mechanisms of their actions. This study provides new knowledge to better understand cancer development and to identify novel therapeutic targets.

Keywords: Dephosphorylation; MYTH; MaMTH; PTP; RTK; phosphorylation; protein phosphatase; protein-protein interaction; signaling.