Molecular mechanisms of human papillomavirus-related carcinogenesis in head and neck cancer

Farhoud Faraji; Munfarid Zaidi; Carole Fakhry; Daria A Gaykalova

doi:10.1016/j.micinf.2017.06.001

Molecular mechanisms of human papillomavirus-related carcinogenesis in head and neck cancer

Microbes Infect. 2017 Sep-Oct;19(9-10):464-475. doi: 10.1016/j.micinf.2017.06.001. Epub 2017 Jun 12.

Authors

Farhoud Faraji¹, Munfarid Zaidi¹, Carole Fakhry¹, Daria A Gaykalova²

Affiliations

¹ Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
² Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: [email protected].

Abstract

This review examines the general cellular and molecular underpinnings of human papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell carcinoma (HNSCC) and focuses on HPV-positive oropharyngeal squamous cell carcinoma in areas for which specific data is available. It covers the major pathways dysregulated in HPV-positive HNSCC and the genome-wide changes associated with this disease.

Keywords: Chromatin; HNSCC; HPV; Oropharyngeal; Squamous cell carcinoma; Viral integration.

Publication types

Review

MeSH terms

Carcinogenesis*
Carcinoma, Squamous Cell / virology*
Head and Neck Neoplasms / virology*
Humans
Papillomaviridae / physiology*
Papillomavirus Infections / complications*
Squamous Cell Carcinoma of Head and Neck

Grants and funding

R21 DE025398/DE/NIDCR NIH HHS/United States