Abstract
Acquired-immunodeficiency-syndrome (AIDS)-associated retroviruses (ARV) have been isolated from the cerebrospinal fluid and brain of homosexual men presenting with neurological symptoms. Most of these patients also met the clinical criteria for AIDS. The viruses grew readily in peripheral mononuclear cells and were identified by their induction of cytopathic effects and ARV antigens in culture. The results suggest that ARV could be the cause of the neurological syndromes in AIDS patients and indicate that the virus can infect cells other than T lymphocytes.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / complications
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Acquired Immunodeficiency Syndrome / microbiology*
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Adult
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Antibodies, Viral / analysis
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Antibodies, Viral / cerebrospinal fluid
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Brain / cytology
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Brain / microbiology*
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Central Nervous System Diseases / complications
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Central Nervous System Diseases / microbiology*
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Cerebrospinal Fluid / microbiology*
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Deltaretrovirus / immunology
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Deltaretrovirus / isolation & purification
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Humans
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Male
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Middle Aged
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Retroviridae / immunology
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Retroviridae / isolation & purification*