Classification of pancreaticobiliary maljunction and clinical features in children

J Hepatobiliary Pancreat Sci. 2017 Aug;24(8):449-455. doi: 10.1002/jhbp.485. Epub 2017 Jul 31.

Abstract

Background: In 2015, the Committee on Diagnostic Criteria of the Japanese Study Group on Pancreaticobiliary Maljunction (PBM) proposed a classification of PBM into four types: (A) stenotic type, (B) non-stenotic type, (C) dilated channel type, and (D) complex type. To validate this classification and clarify the clinical features of the four types of PBM, a retrospective multicenter study was conducted.

Methods: The study group of 317 children with PBM was divided into the four types of PBM. Clinical features, preoperative complications, operations, and postoperative pancreatic complications were evaluated.

Results: All patients underwent excision of the extrahepatic bile duct. In type A, the age was younger and there was a higher incidence of cystic dilatation. Non-dilatation of the common bile duct was frequently seen in type B. Abdominal pain with hyperamylasemia was frequently seen in types B and C. In particular, the incidence of protein plugs and biliary perforation was high in type C (56.1% and 14.3%, respectively). The overall incidence of acute pancreatitis was 7.3%. Pancreatitis after excisional surgery was rare in the children in this study. Two patients with type D (0.6%) developed chronic pancreatitis postoperatively.

Conclusions: This proposed classification is simple and correlates well with clinical features.

Keywords: Choledochal cyst; Classification; Congenital biliary dilatation; Pancreaticobiliary maljunction; Pancreatitis.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Biliary Tract / abnormalities*
  • Biliary Tract Diseases / classification*
  • Biliary Tract Diseases / mortality
  • Biliary Tract Diseases / surgery
  • Child
  • Child, Preschool
  • Cholangiopancreatography, Endoscopic Retrograde / methods
  • Cohort Studies
  • Digestive System Abnormalities / diagnosis*
  • Digestive System Abnormalities / epidemiology
  • Digestive System Abnormalities / surgery
  • Female
  • Humans
  • Incidence
  • Japan / epidemiology
  • Male
  • Pancreatic Diseases / classification*
  • Pancreatic Diseases / mortality
  • Pancreatic Diseases / surgery
  • Pancreatic Ducts / abnormalities*
  • Pancreatic Ducts / surgery
  • Prognosis
  • Retrospective Studies
  • Risk Assessment
  • Statistics, Nonparametric
  • Survival Rate
  • Tomography, X-Ray Computed / methods