Abstract
A phytochemical investigation of the alkaloid constituents from Trigonostemon filipes Y. T. Chang et S. L. Mo led to the isolation of two new indole alkaloids, trigonostemine G (1) and trigonostemone J (2), together with two known ones, trigonostemine A (3) and trigonostemine B (4). Their structures were determined by extensive spectroscopic methods. Compounds 1-4 exhibited moderate AChE inhibitory activity with inhibition ratio of 31.6, 31.7, 41.7, and 42.4%, respectively. In addition, compounds 1-2 showed weak cytotoxicity against K562 and BEL-7402 human cancer cell lines.
Keywords:
AChE inhibitory activity; Euphorbiaceae; Trigonostemon filipes; cytotoxicity; indole alkaloids.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / isolation & purification*
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Cholinesterase Inhibitors / pharmacology
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Drug Screening Assays, Antitumor
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Euphorbiaceae / chemistry*
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Humans
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification*
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Indole Alkaloids / pharmacology
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K562 Cells
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Stems / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Cholinesterase Inhibitors
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Indole Alkaloids
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trigonostemine G
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trigonostemine J