Prophylactic Treatment with VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection

Teclegiorgis Gebremariam; Sondus Alkhazraji; Lin Lin; Nathan P Wiederhold; Edward P Garvey; William J Hoekstra; Robert J Schotzinger; Thomas F Patterson; Scott G Filler; Ashraf S Ibrahim

doi:10.1128/AAC.00390-17

Prophylactic Treatment with VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection

Antimicrob Agents Chemother. 2017 Aug 24;61(9):e00390-17. doi: 10.1128/AAC.00390-17. Print 2017 Sep.

Authors

Teclegiorgis Gebremariam¹, Sondus Alkhazraji¹, Lin Lin^{1

2}, Nathan P Wiederhold³, Edward P Garvey⁴, William J Hoekstra⁴, Robert J Schotzinger⁴, Thomas F Patterson^{3

5}, Scott G Filler^{1

2}, Ashraf S Ibrahim^{6

2}

Affiliations

¹ Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA.
² David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
³ University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
⁴ Viamet Pharmaceuticals, Inc., Durham, North Carolina, USA.
⁵ South Texas Veterans Health Care System, San Antonio, Texas, USA.
⁶ Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and St. John's Cardiovascular Research Center, Torrance, California, USA [email protected].

Abstract

We compared prophylactic or continuous therapy with the investigational drug VT-1161 to that with posaconazole in treating murine mucormycosis due to Rhizopus arrhizus var. arrhizus In the prophylaxis studies, only VT-1161 resulted in improved survival and lowered tissue fungal burden of immunosuppressed infected mice. In the continuous therapy, VT-1161 outperformed posaconazole in prolonging mouse survival time despite its comparable effect in lowering tissue fungal burden. These results support the further development of VT-1161 against mucormycosis.

Keywords: Rhizopus arrhizus; VT-1161; mucormycosis; murine; prophylaxis.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Antifungal Agents / pharmacology*
Immunocompromised Host
Male
Mice
Microbial Sensitivity Tests / methods
Mucormycosis / drug therapy
Mucormycosis / microbiology
Protective Agents / pharmacology*
Pyridines / pharmacology*
Rhizopus / drug effects*
Tetrazoles / pharmacology*
Triazoles / pharmacology

Substances

Antifungal Agents
Protective Agents
Pyridines
Tetrazoles
Triazoles
VT-1161
posaconazole

Abstract

Publication types

MeSH terms

Substances

Grants and funding