Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017

Silke Gillessen; Gerhardt Attard; Tomasz M Beer; Himisha Beltran; Alberto Bossi; Rob Bristow; Brett Carver; Daniel Castellano; Byung Ha Chung; Noel Clarke; Gedske Daugaard; Ian D Davis; Johann de Bono; Rodolfo Borges Dos Reis; Charles G Drake; Ros Eeles; Eleni Efstathiou; Christopher P Evans; Stefano Fanti; Felix Feng; Karim Fizazi; Mark Frydenberg; Martin Gleave; Susan Halabi; Axel Heidenreich; Celestia S Higano; Nicolas James; Philip Kantoff; Pirkko-Liisa Kellokumpu-Lehtinen; Raja B Khauli; Gero Kramer; Chris Logothetis; Fernando Maluf; Alicia K Morgans; Michael J Morris; Nicolas Mottet; Vedang Murthy; William Oh; Piet Ost; Anwar R Padhani; Chris Parker; Colin C Pritchard; Mack Roach; Mark A Rubin; Charles Ryan; Fred Saad; Oliver Sartor; Howard Scher; Avishay Sella; Neal Shore; Matthew Smith; Howard Soule; Cora N Sternberg; Hiroyoshi Suzuki; Christopher Sweeney; Matthew R Sydes; Ian Tannock; Bertrand Tombal; Riccardo Valdagni; Thomas Wiegel; Aurelius Omlin

doi:10.1016/j.eururo.2017.06.002

Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017

Eur Urol. 2018 Feb;73(2):178-211. doi: 10.1016/j.eururo.2017.06.002. Epub 2017 Jun 24.

Authors

Silke Gillessen¹, Gerhardt Attard², Tomasz M Beer³, Himisha Beltran⁴, Alberto Bossi⁵, Rob Bristow⁶, Brett Carver⁷, Daniel Castellano⁸, Byung Ha Chung⁹, Noel Clarke¹⁰, Gedske Daugaard¹¹, Ian D Davis¹², Johann de Bono², Rodolfo Borges Dos Reis¹³, Charles G Drake¹⁴, Ros Eeles¹⁵, Eleni Efstathiou¹⁶, Christopher P Evans¹⁷, Stefano Fanti¹⁸, Felix Feng¹⁹, Karim Fizazi²⁰, Mark Frydenberg²¹, Martin Gleave²², Susan Halabi²³, Axel Heidenreich²⁴, Celestia S Higano²⁵, Nicolas James²⁶, Philip Kantoff²⁷, Pirkko-Liisa Kellokumpu-Lehtinen²⁸, Raja B Khauli²⁹, Gero Kramer³⁰, Chris Logothetis³¹, Fernando Maluf³², Alicia K Morgans³³, Michael J Morris³⁴, Nicolas Mottet³⁵, Vedang Murthy³⁶, William Oh³⁷, Piet Ost³⁸, Anwar R Padhani³⁹, Chris Parker⁴⁰, Colin C Pritchard⁴¹, Mack Roach¹⁹, Mark A Rubin⁴², Charles Ryan⁴³, Fred Saad⁴⁴, Oliver Sartor⁴⁵, Howard Scher⁴⁶, Avishay Sella⁴⁷, Neal Shore⁴⁸, Matthew Smith⁴⁹, Howard Soule⁵⁰, Cora N Sternberg⁵¹, Hiroyoshi Suzuki⁵², Christopher Sweeney⁵³, Matthew R Sydes⁵⁴, Ian Tannock⁵⁵, Bertrand Tombal⁵⁶, Riccardo Valdagni⁵⁷, Thomas Wiegel⁵⁸, Aurelius Omlin⁵⁹

Affiliations

¹ Department of Medical Oncology, Cantonal Hospital St. Gallen and University of Berne, Switzerland. Electronic address: [email protected].
² Department of Medical Oncology, The Institute of Cancer Research/Royal Marsden, London, UK.
³ Oregon Health & Science University Knight Cancer Institute, OR, USA.
⁴ Department of Medical Oncology, Weill Cornell Medicine, New York, NY, USA.
⁵ Department of Radiation Oncology, Genito Urinary Oncology, Prostate Brachytherapy Unit, Goustave Roussy, Paris, France.
⁶ Department of Radiation Oncology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON, USA.
⁷ Department of Urology, Sidney Kimmel Center for Prostate and Urologic Cancers, New York, NY, USA.
⁸ Department of Medical Oncology, Hospital Universitario 12 de Octubre, Madrid, Spain.
⁹ Department of Urology, Gangnam Severance Hospital, Yonsei University Health System, Seoul, Korea.
¹⁰ Department of Urology, The Christie and Salford Royal Hospitals, Manchester, UK.
¹¹ Department of Medical Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
¹² Monash University and Eastern Health, Eastern Health Clinical School, Box Hill, Australia.
¹³ Department of Urology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
¹⁴ Department of Medical Oncology, Division of Haematology/Oncology, Columbia University Medical Center, New York, NY, USA.
¹⁵ Department of Clinical Oncology and Genetics, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
¹⁶ Department of Medical Oncology, University of Texas MD Anderson Cancer Center, TX, USA.
¹⁷ Department of Urology, University of California, Davis School of Medicine, CA, USA.
¹⁸ Department of Nuclear Medicine, Policlinico S. Orsola, Università di Bologna, Italy.
¹⁹ Department of Radiation Oncology, University of California, San Francisco, CA, USA.
²⁰ Department of Medical Oncology, Gustave Roussy, University of Paris Sud, Paris, France.
²¹ Department of Surgery, Department of Anatomy and Developmental Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University.
²² Department of Urology, Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada.
²³ Department of Clinical trials and Statistics, Duke University, Durham, NC, USA.
²⁴ Department of Urology, University Hospital Köln, Köln, Germany.
²⁵ Department of Medicine, Division of Medical Oncology, University of Washington and Fred Hutchinson Cancer Research Center, WA, USA.
²⁶ Department of Clinical Oncology, Clinical Oncology Queen Elizabeth Hospital Birmingham and University of Birmingham, Birmingham, UK.
²⁷ Department of Medical Oncology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA.
²⁸ Department of Clinical Oncology, Tampere University Hospital, Faculty of Medicine and Life Sciences, University of Tampere, Finland.
²⁹ Department of Urology, American University of Beirut Medical Center, Beirut, Lebanon.
³⁰ Department of Urology, Medical University of Vienna, Vienna, Austria.
³¹ Department of Genitourinary Medical Oncology, MD Anderson Cancer Centre, Houston, TX, USA.
³² Department of Medical Oncology Hospital Israelita Albert Einstein and Department of Medical Oncology Beneficência Portuguesa de São Paulo.
³³ Department of Medical Oncology and Epidemiology, Vanderbilt University Medical Center, Division of Hematology/Oncology, Nashville, TN, USA.
³⁴ Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
³⁵ Department of Urology, University Hospital Nord St. Etienne, St. Etienne, France.
³⁶ Department of Radiation Oncology, Tata Memorial Centre, Mumbai, India.
³⁷ Department of Medical Oncology, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, The Tisch Cancer Institute, New York, NY, USA.
³⁸ Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
³⁹ Department of Radiology, Mount Vernon Cancer Centre and Institute of Cancer Research, London, UK.
⁴⁰ Department of Clinical Oncology, Royal Marsden NHS Foundation Trust, Sutton, UK.
⁴¹ Department of Pathology, University of Washington, WA, USA.
⁴² Department of Pathology, University of Bern and the Inselspital, Bern (CH).
⁴³ Department of Medical Oncology, Clinical Medicine and Urology at the Helen Diller Family Comprehensive Cancer Center at the University of, California, San Francisco, CA, USA.
⁴⁴ Department of Urology, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.
⁴⁵ Department of Medical Oncology, Tulane Cancer Center, New Orleans, LA, USA.
⁴⁶ Department of Medical Oncology, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Centre, New York, NY, USA.
⁴⁷ Department of Medical Oncology, Department of Oncology, Assaf Harofeh Medical Centre, Tel-Aviv University, Sackler School of Medicine, Zerifin, Israel.
⁴⁸ Department of Urology, Carolina Urologic Research Center, Myrtle Beach, SC, USA.
⁴⁹ Department of Medical Oncology, Massachusetts General Hospital Cancer Centre, Boston, MA, USA.
⁵⁰ Prostate Cancer Foundation, Santa Monica, CA, USA.
⁵¹ Department of Medical Oncology, San Camillo Forlanini Hospital, Rome, Italy.
⁵² Department of Urology, Toho University Sakura Medical Center, Japan.
⁵³ Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁵⁴ MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK.
⁵⁵ Department of Medical Oncology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON, Canada.
⁵⁶ Department of Urology, Cliniques Universitaires Saint Luc, Brussels, Belgium.
⁵⁷ Department of Oncology and Haemato-oncology, Università degli Studi di Milano. Radiation Oncology 1, Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
⁵⁸ Department of Radiation Oncology, Klinik für Strahlentherapie und Radioonkologie des Universitätsklinikum Ulm, Albert-Einstein-Allee, Ulm, Germany.
⁵⁹ Department of Medical Oncology, Cantonal Hospital St. Gallen and University of Berne, Switzerland.

PMID: 28655541
DOI: 10.1016/j.eururo.2017.06.002

Abstract

Background: In advanced prostate cancer (APC), successful drug development as well as advances in imaging and molecular characterisation have resulted in multiple areas where there is lack of evidence or low level of evidence. The Advanced Prostate Cancer Consensus Conference (APCCC) 2017 addressed some of these topics.

Objective: To present the report of APCCC 2017.

Design, setting, and participants: Ten important areas of controversy in APC management were identified: high-risk localised and locally advanced prostate cancer; "oligometastatic" prostate cancer; castration-naïve and castration-resistant prostate cancer; the role of imaging in APC; osteoclast-targeted therapy; molecular characterisation of blood and tissue; genetic counselling/testing; side effects of systemic treatment(s); global access to prostate cancer drugs. A panel of 60 international prostate cancer experts developed the program and the consensus questions.

Outcome measurements and statistical analysis: The panel voted publicly but anonymously on 150 predefined questions, which have been developed following a modified Delphi process.

Results and limitations: Voting is based on panellist opinion, and thus is not based on a standard literature review or meta-analysis. The outcomes of the voting had varying degrees of support, as reflected in the wording of this article, as well as in the detailed voting results recorded in Supplementary data.

Conclusions: The presented expert voting results can be used for support in areas of management of men with APC where there is no high-level evidence, but individualised treatment decisions should as always be based on all of the data available, including disease extent and location, prior therapies regardless of type, host factors including comorbidities, as well as patient preferences, current and emerging evidence, and logistical and economic constraints. Inclusion of men with APC in clinical trials should be strongly encouraged. Importantly, APCCC 2017 again identified important areas in need of trials specifically designed to address them.

Patient summary: The second Advanced Prostate Cancer Consensus Conference APCCC 2017 did provide a forum for discussion and debates on current treatment options for men with advanced prostate cancer. The aim of the conference is to bring the expertise of world experts to care givers around the world who see less patients with prostate cancer. The conference concluded with a discussion and voting of the expert panel on predefined consensus questions, targeting areas of primary clinical relevance. The results of these expert opinion votes are embedded in the clinical context of current treatment of men with advanced prostate cancer and provide a practical guide to clinicians to assist in the discussions with men with prostate cancer as part of a shared and multidisciplinary decision-making process.

Keywords: Advanced and high-risk localized prostate cancer; Castration-naive and castration-resistant prostate cancer; Consensus; Oligometastatic prostate cancer; Therapeutics.

Publication types

Consensus Development Conference
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Male
Neoplasm Staging
Practice Guidelines as Topic
Prostatic Neoplasms / diagnosis*
Prostatic Neoplasms / pathology
Prostatic Neoplasms / therapy*

Abstract

Publication types

MeSH terms

Grants and funding