Discovery of 2-hydroxyarbekacin, a new aminoglycoside antibiotic with reduced nephrotoxicity

MeSH terms

• Aminoglycosides / adverse effects*
• Aminoglycosides / chemical synthesis*
• Aminoglycosides / pharmacology
• Animals
• Anti-Bacterial Agents / adverse effects*
• Anti-Bacterial Agents / chemical synthesis*
• Anti-Bacterial Agents / pharmacology
• Drug Discovery
• Kidney Diseases / chemically induced*
• Kidney Diseases / pathology
• Kidney Function Tests
• LLC-PK1 Cells
• Methicillin-Resistant Staphylococcus aureus / drug effects
• Microbial Sensitivity Tests
• Molecular Conformation
• Pseudomonas aeruginosa / drug effects
• Rats
• Swine