mTORC1 Controls Synthesis of Its Activator GTP

Don Benjamin; Michael N Hall

doi:10.1016/j.celrep.2017.06.032

mTORC1 Controls Synthesis of Its Activator GTP

Cell Rep. 2017 Jun 27;19(13):2643-2644. doi: 10.1016/j.celrep.2017.06.032.

Authors

Don Benjamin¹, Michael N Hall²

Affiliations

¹ Biozentrum, University of Basel, 4056 Basel, Switzerland.
² Biozentrum, University of Basel, 4056 Basel, Switzerland. Electronic address: [email protected].

PMID: 28658613
DOI: 10.1016/j.celrep.2017.06.032

Abstract

In this issue of Cell Reports, Emmanuel et al. (2017) report that mTORC1 activity is regulated by purine availability. This increases the number of mTORC1 regulators to include metabolites whose synthesis mTORC1 controls.

Publication types

Review

MeSH terms

Humans
Mechanistic Target of Rapamycin Complex 1 / metabolism*
Monomeric GTP-Binding Proteins / metabolism*
TOR Serine-Threonine Kinases / metabolism*

Substances

Mechanistic Target of Rapamycin Complex 1
TOR Serine-Threonine Kinases
Monomeric GTP-Binding Proteins