NOTCH1 mutational status in chronic lymphocytic leukaemia: clinical relevance of subclonal mutations and mutation types

Br J Haematol. 2018 Aug;182(4):597-602. doi: 10.1111/bjh.14843. Epub 2017 Jul 12.

¹ Clinical and Experimental Onco-Haematology Unit, Centro di Riferimento Oncologico, I.R.C.C.S., Aviano, PN, Italy.
² Onco-Haematology Department, Centro di Riferimento Oncologico della Basilicata, I.R.C.C.S., Rionero in Vulture, Italy.
³ Division of Haematology, Ferrarotto Hospital, Catania, Italy.
⁴ Clinica Ematologica, Centro Trapianti e Terapie Cellulari "Carlo Melzi" DISM, Azienda Ospedaliera Universitaria S. Maria Misericordia, Udine, Italy.
⁵ Department of Internal Medicine and Haematology, Maggiore General Hospital, University of Trieste, Trieste, Italy.
⁶ Haematology, Institute of Oncology Research and Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
⁷ Division of Haematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.
⁸ Division of Haematology, S. Eugenio Hospital and University of Tor Vergata, Rome, Italy.

No abstract available

Keywords: NOTCH1 mutations; chronic lymphocytic leukaemia; overall survival; progression-free survival.

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