Wiesner Nevus of the Eyelid

Ophthalmic Plast Reconstr Surg. 2018 Jan/Feb;34(1):e13-e16. doi: 10.1097/IOP.0000000000000958.

Abstract

A healthy 31-year-old female presented with an elevated vascular lesion on the right lower eyelid margin. Histology results from excisional biopsy demonstrated a range of intradermally nested atypical melanocytes with negative staining for BRCA1-associated protein 1, confirming the diagnosis of Wiesner nevus. Wiesner nevi may be a cutaneous hallmark of the BRCA1-associated protein 1-associated cancer susceptibility syndrome, and to our knowledge, this is the first report of such a lesion presenting anywhere on the ocular adnexa.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • BRCA1 Protein / metabolism*
  • Biomarkers, Tumor / metabolism
  • Biopsy
  • Diagnosis, Differential
  • Eyelid Neoplasms / diagnosis*
  • Eyelid Neoplasms / metabolism
  • Eyelids / pathology*
  • Female
  • Humans
  • Immunohistochemistry
  • Nevus / diagnosis*
  • Nevus / metabolism

Substances

  • BRCA1 Protein
  • BRCA1 protein, human
  • Biomarkers, Tumor