Zinc-promoted cyclization of tosylhydrazones and 2-(dimethylamino)malononitrile: an efficient strategy for the synthesis of substituted 1-tosyl-1H-pyrazoles
1 School of Pharmacy, Lanzhou University, Lanzhou 730000, P. R. China. [email protected].
2 School of Pharmacy, Lanzhou University, Lanzhou 730000, P. R. China. [email protected] and School of Chemical and Environmental Engineering, Wuyi University, Jiangmen 529020, P. R. China and Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, Sichuan University, Chengdu, P. R. China.
3 School of Chemical and Environmental Engineering, Wuyi University, Jiangmen 529020, P. R. China.
A Zn(OTf)2-promoted cyclization reaction of tosylhydrazones with 2-(dimethylamino)malononitrile has been successfully developed providing an efficient strategy for the synthesis of substituted 1-tosyl-1H-pyrazoles.