Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer

Juming Yan; Mark J Smyth; Michele W L Teng

doi:10.1101/cshperspect.a028530

Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer

Cold Spring Harb Perspect Biol. 2018 Jul 2;10(7):a028530. doi: 10.1101/cshperspect.a028530.

Authors

Juming Yan^{1

2}, Mark J Smyth^{2

3}, Michele W L Teng^{1

2}

Affiliations

¹ Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston 4006, Queensland, Australia.
² School of Medicine, University of Queensland, Herston 4006, Queensland, Australia.
³ Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston 4006, Queensland, Australia.

Abstract

The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity. In this review, we discuss the role IL-12 and IL-23 plays in tumor biology from preclinical and clinical data. In particular, we discuss the mechanism by which IL-23 promotes tumor growth and metastases and how the IL-12/IL-23 axis of inflammation can be targeted for cancer therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Gene Expression Regulation, Neoplastic / physiology*
Humans
Interleukin-12 / genetics
Interleukin-12 / metabolism*
Interleukin-23 / genetics
Interleukin-23 / metabolism*
Neoplasms / metabolism*

Substances

Interleukin-23
Interleukin-12