Abstract
4-Monomethylaminoantipyrine (MAA)-induced increase of hepatic drug metabolizing enzymes was suppressed by SKF 525-A. This may be due to the partial binding of SKF 525-A to a portion of cytochrome P-450. On the other hand, glutathione S-transferase and gamma-glutamyltranspeptidase (gamma-GTP) activities of rat liver were both induced by repeated administration of MAA in combination with SKF 525-A. In addition, under the same condition, glutathione level in rat liver was significantly decreased.
MeSH terms
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Aminopyrine / analogs & derivatives*
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Aminopyrine N-Demethylase / metabolism
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Animals
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Cytosol / analysis
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Dipyrone / administration & dosage
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Dipyrone / analogs & derivatives*
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Dipyrone / pharmacology
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Glutathione / analysis
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Glutathione Transferase / metabolism*
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Liver / drug effects*
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Liver / enzymology
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Male
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Mixed Function Oxygenases / metabolism*
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Proadifen / administration & dosage
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Proadifen / pharmacology*
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Pyrazolones*
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Rats
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Rats, Inbred Strains
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gamma-Glutamyltransferase / metabolism*
Substances
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Pyrazolones
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Aminopyrine
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Dipyrone
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Proadifen
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Mixed Function Oxygenases
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Aminopyrine N-Demethylase
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gamma-Glutamyltransferase
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Glutathione Transferase
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Glutathione
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noramidopyrine