Electron-Deficient Chiral Lactic Acid-Based Hypervalent Iodine Reagents

J Org Chem. 2017 Nov 17;82(22):11872-11876. doi: 10.1021/acs.joc.7b01571. Epub 2017 Jul 31.

Abstract

Novel electron-deficient chiral hypervalent iodine reagents were prepared in good overall yields. The reactivity and stereoselectivity of these reagents in oxidative rearrangements of alkenes to α-aryl ketones were investigated. The results show that the new reagents have good reactivity and generate products with high enantiomeric excess.

Publication types

  • Research Support, Non-U.S. Gov't