Influenza: A Global Perspective

Elizabeth T Rotrosen; Kathleen M Neuzil

doi:10.1016/j.pcl.2017.03.007

Influenza: A Global Perspective

Pediatr Clin North Am. 2017 Aug;64(4):911-936. doi: 10.1016/j.pcl.2017.03.007.

Authors

Elizabeth T Rotrosen¹, Kathleen M Neuzil²

Affiliations

¹ Center for Vaccine Development, University of Maryland, School of Medicine, 685 West Baltimore Street, Room 480, Baltimore, MD 21201, USA.
² Center for Vaccine Development, University of Maryland, School of Medicine, 685 West Baltimore Street, Room 480, Baltimore, MD 21201, USA. Electronic address: [email protected].

PMID: 28734518
DOI: 10.1016/j.pcl.2017.03.007

Abstract

Influenza is a common respiratory illness in children and accounts for substantial morbidity and mortality on an annual basis. Inactivated and live influenza vaccines are approved for children and are safe and efficacious. The absolute effectiveness of vaccines varies by year and is influenced by several factors. The reason for recent reduced performance of live-attenuated influenza vaccines is poorly understood, and active research is ongoing. Vaccination programs are less common in tropical and subtropical countries, where unique logistical and feasibility challenges exist. Antiviral medications for prevention and treatment of influenza in children are an important adjunct to vaccines.

Keywords: Antiviral medications; Children; Influenza; Influenza vaccines; Vaccine policy.

Publication types

Review

MeSH terms

Antiviral Agents / therapeutic use*
Child
Global Health
Humans
Immunization Programs / methods*
Influenza Vaccines*
Influenza, Human / drug therapy
Influenza, Human / prevention & control*

Substances

Antiviral Agents
Influenza Vaccines