Descriptive epidemiology of primary malignant and non-malignant central nervous tumors in Spain: Results from the Girona Cancer Registry (1994-2013)

Rafael Fuentes-Raspall; Marta Solans; Aina Roca-Barceló; Loreto Vilardell; Montse Puigdemont; Sonia Del Barco; Raquel Comas; Adelaida García-Velasco; Aurora Astudillo; Mª Carme Carmona-Garcia; Rafael Marcos-Gragera

doi:10.1016/j.canep.2017.07.005

Descriptive epidemiology of primary malignant and non-malignant central nervous tumors in Spain: Results from the Girona Cancer Registry (1994-2013)

Cancer Epidemiol. 2017 Oct;50(Pt A):1-8. doi: 10.1016/j.canep.2017.07.005. Epub 2017 Jul 21.

Affiliations

¹ Radiation Oncology Service, Josep Trueta University Hospital, Catalan Institute of Oncology, Avinguda de França, S/N, 17007 Girona, Spain. Electronic address: [email protected].
² CIBER in Epidemiology and Public Health (CIBERESP), University of Girona (UdG), C/ Universitat de Girona 10,17003 Girona, Spain, Spain; Research Group on Statistics, Econometrics and Health (GRECS), University of Girona (UdG), C/ Universitat de Girona 10,17003 Girona, Spain; Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Carrer del Sol, 15, 17004 Girona, Spain. Electronic address: [email protected].
³ Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Carrer del Sol, 15, 17004 Girona, Spain. Electronic address: [email protected].
⁴ Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Carrer del Sol, 15, 17004 Girona, Spain. Electronic address: [email protected].
⁵ Hospital Cancer Registry, Josep Trueta University Hospital, Catalan Institute of Oncology, Av de França, 17007, Girona, Spain; Nursing Department, University of Girona, Av de França, 17007, Girona, Spain. Electronic address: [email protected].
⁶ Medical Oncology Service, Josep Trueta University Hospital, Catalan Institute of Oncology, Av de França, 17007, Girona, Spain. Electronic address: [email protected].
⁷ Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Carrer del Sol, 15, 17004 Girona, Spain. Electronic address: [email protected].
⁸ Medical Oncology Service, Josep Trueta University Hospital, Catalan Institute of Oncology, Av de França, 17007, Girona, Spain. Electronic address: [email protected].
⁹ Department of Pathology, Central University Hospital of Asturias (HUCA), Av. de Roma, 33006 Oviedo, Spain. Electronic address: [email protected].
¹⁰ Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Carrer del Sol, 15, 17004 Girona, Spain; Emergency Department, Josep Trueta University Hospital, Catalan Institute of Oncology, Av de França, 17007, Girona, Spain. Electronic address: [email protected].
¹¹ Research Group on Statistics, Econometrics and Health (GRECS), University of Girona (UdG), C/ Universitat de Girona 10,17003 Girona, Spain; Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Carrer del Sol, 15, 17004 Girona, Spain. Electronic address: [email protected].

PMID: 28738268
DOI: 10.1016/j.canep.2017.07.005

Abstract

Background: Systematic registration of non-malignant central nervous system (CNS) tumors is a rare practice among European cancer registries. Thus, the real burden of all CNS tumors across Europe is underestimated. The Girona Cancer Registry provides here the first data on CNS tumor incidence and survival trends in Spain for all histological types, including malignant and non-malignant tumors.

Methods: Data on all incident cases of primary CNS tumors notified to the Girona population-based cancer registry from 1994 to 2013 (n=2,131) were reviewed. Incidences rates (IRs) were standardized to the 2013 European population and annual percentage changes (EAPC) were estimated using a piecewise log linear model. 1- and 5-year observed (OS) and relative survival (RS) were also calculated. Results were expressed by sex, age-group, histological subtype and behavior.

Results: The overall IR was 16.85 and increased across the period of study (EAPC=+2.2%). The proportion and IRs of malignant (50.2%; IR=9.35) and non-malignant cases (49.8%; IR=9.14) were similar; however, non-malignant tumors were more frequent in women (sex ratio=0.63). The most frequently reported histologies were meningioma (27.6%; IR=5.11) and glioblastoma (22.2%; IR=4.15), which also accounted for the highest and lowest 5-year RS (80.2%; 3.7%, respectively). Globally, 5-year RS was lower in men (42.6% vs. 58.3%, respectively) and in the elderly (64.9% for 0-14years vs. 23.0% for >74years).

Conclusion: This study presents a comprehensive overview of the epidemiology of malignant and non-malignant CNS primary tumors from the well-established region-wide Girona Cancer Registry (1994-2013). Incidence rates were recovered for all histologies. Survival is still dramatically associated to both age and histological subtype.

Keywords: Incidence; Non-malignant; Population-based; Primary central nervous tumors; Spain; Survival.

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Central Nervous System Neoplasms / epidemiology*
Central Nervous System Neoplasms / mortality*
Child
Child, Preschool
Female
Humans
Incidence
Infant
Infant, Newborn
Male
Middle Aged
Prognosis
Registries / statistics & numerical data*
Retrospective Studies
Spain / epidemiology
Survival Rate
Young Adult