RETRACTED: The in vitro and in vivo effects of microRNA-133a on intervertebral disc destruction by targeting MMP9 in spinal tuberculosis

Life Sci. 2017 Nov 1:188:198-205. doi: 10.1016/j.lfs.2017.07.022. Epub 2017 Jul 21.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concern was raised about the reliability of the Western blot results in Figure 4 A+C, which appear to have a similar phenotype as seen in many other publications, as detailed here: https://pubpeer.com/publications/0D0667F09124C7911264C51064AF20; and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. The journal requested that the corresponding author comment on these concerns and provide the raw data. The authors did not respond to this request and therefore the Editor-in-Chief decided to retract the article.

Keywords: Collagen I; Collagen II; Collagen-X; Intervertebral disc; Matrix metallopeptidase 9; Spinal tuberculosis; microRNA-133a.

Publication types

  • Retracted Publication

MeSH terms

  • Animals
  • Cell Count
  • Collagen / biosynthesis
  • Down-Regulation*
  • Female
  • Gene Expression Regulation, Enzymologic*
  • Intervertebral Disc / enzymology
  • Intervertebral Disc / metabolism*
  • Intervertebral Disc / pathology*
  • Male
  • Matrix Metalloproteinase 9 / biosynthesis*
  • Matrix Metalloproteinase 9 / genetics*
  • Matrix Metalloproteinase Inhibitors
  • MicroRNAs / agonists
  • MicroRNAs / antagonists & inhibitors
  • MicroRNAs / genetics*
  • Osteoclasts / pathology
  • Osteoclasts / physiology
  • RNA, Small Interfering / agonists
  • RNA, Small Interfering / antagonists & inhibitors
  • RNA, Small Interfering / genetics
  • Rabbits
  • Tuberculosis, Spinal / metabolism
  • Tuberculosis, Spinal / pathology

Substances

  • MIRN133 microRNA, human
  • Matrix Metalloproteinase Inhibitors
  • MicroRNAs
  • RNA, Small Interfering
  • Collagen
  • Matrix Metalloproteinase 9