The extensive glycosylation of the ACPA variable domain observed for ACPA-IgG is absent from ACPA-IgM

Ann Rheum Dis. 2018 Jul;77(7):1087-1088. doi: 10.1136/annrheumdis-2017-211533. Epub 2017 Jul 26.

Affiliations

¹ Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
² Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands.
³ Department of Rheumatology, Groene Hart Ziekenhuis, Gouda, The Netherlands.

PMID: 28747327
DOI: 10.1136/annrheumdis-2017-211533

No abstract available

Keywords: Ant-ccp; Autoantibodies; Rheumatoid Arthritis.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Citrullinated Protein Antibodies / metabolism*
Arthritis, Rheumatoid / immunology*
Arthritis, Rheumatoid / physiopathology
Autoantibodies / metabolism
Case-Control Studies
Female
Glycosylation
Humans
Immunoglobulin G / metabolism
Immunoglobulin M / metabolism*
Male
Mass Spectrometry
Middle Aged
Peptides, Cyclic / immunology*
Rheumatoid Factor / blood*
Sensitivity and Specificity
Severity of Illness Index
Statistics, Nonparametric

Substances

Anti-Citrullinated Protein Antibodies
Autoantibodies
Immunoglobulin G
Immunoglobulin M
Peptides, Cyclic
Rheumatoid Factor