Label-free molecular imaging of the kidney

Boone M Prentice; Richard M Caprioli; Vincent Vuiblet

doi:10.1016/j.kint.2017.03.052

Label-free molecular imaging of the kidney

Kidney Int. 2017 Sep;92(3):580-598. doi: 10.1016/j.kint.2017.03.052. Epub 2017 Jul 24.

Authors

Boone M Prentice¹, Richard M Caprioli², Vincent Vuiblet³

Affiliations

¹ Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA; Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee, USA.
² Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, USA; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA; Departments of Pharmacology and Medicine, Vanderbilt University, Nashville, Tennessee, USA; Mass Spectrometry Research Center, Vanderbilt University, Nashville, Tennessee, USA. Electronic address: [email protected].
³ Biophotonic Laboratory, UMR CNRS 7369 URCA, Reims, France; Nephropathology, Department of Biopathology Laboratory, CHU de Reims, Reims, France; Nephrology and Renal Transplantation department, CHU de Reims, Reims, France. Electronic address: [email protected].

Abstract

In this review, we will highlight technologies that enable scientists to study the molecular characteristics of tissues and/or cells without the need for antibodies or other labeling techniques. Specifically, we will focus on matrix-assisted laser desorption/ionization imaging mass spectrometry, infrared spectroscopy, and Raman spectroscopy.

Keywords: advanced-glycation end products; cancer; fibrosis; inflammation; renal biopsy; renal pathology.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Humans
Kidney / pathology
Kidney Diseases / pathology*
Molecular Imaging / methods*
Molecular Imaging / trends
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*
Spectrophotometry, Infrared / methods*
Spectrum Analysis, Raman / methods*
Vibration

Abstract

Publication types

MeSH terms

Grants and funding