Recommendations of the Brazilian Society of Rheumatology for the induction therapy of ANCA-associated vasculitis

Rev Bras Reumatol Engl Ed. 2017:57 Suppl 2:484-496. doi: 10.1016/j.rbre.2017.06.003. Epub 2017 Jul 25.
[Article in English, Portuguese]

Abstract

The purpose of these recommendations is to guide the appropriate induction treatment of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) patients with active disease. The recommendations proposed by the Vasculopathies Committee of the Brazilian Society Rheumatology for induction therapy of AAV, including granulomatosis with polyangiitis, microscopic polyangiitis and renal-limited vasculitis, were based on systematic literature review and expert opinion. Literature review was performed using Medline (PubMed), EMBASE and Cochrane database to retrieve articles until October 2016. PRISMA guidelines were used for the systematic review and articles were assessed according to the Oxford levels of evidence. Sixteen recommendations were made regarding different aspects of induction therapy for AAV. The purpose of these recommendations is to serve as a guide for therapeutic decisions by health care professionals in the management of AAV patients presenting active disease.

Keywords: ANCA-associated vasculitis; Diretrizes; Granulomatose com poliangiite; Granulomatosis with polyangiitis; Guidelines; Microscopic polyangiitis; Poliangiite microscópica; Renal-limited vasculitis; Vasculite associada a ANCA; Vasculite limitada ao rim.

Publication types

  • Research Support, Non-U.S. Gov't
  • Systematic Review

MeSH terms

  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / drug therapy*
  • Brazil
  • Consensus
  • Humans
  • Rheumatology
  • Societies, Medical