Systemic Sarcoidosis with Thyroid Involvement

Intern Med. 2017 Aug 15;56(16):2181-2186. doi: 10.2169/internalmedicine.8324-16. Epub 2017 Aug 1.

Abstract

A 66-year-old woman, who was diagnosed with iritis, visited our hospital due to general malaise. A blood analysis revealed hypercalcemia. Computed tomography revealed mediastinal and hilar lymph node hyperplasia. Moreover, 67Gallium scintigraphy demonstrated strong accumulation in the lesions, suggesting sarcoidosis. A core needle biopsy (CNB) of the hypoechoic areas of the thyroid was performed because the patient refused to undergo a bronchoscopic examination. The scattering of slightly acidophilic epithelioid cell granulomas was observed in the pathological examination of the biopsy specimen. Based on this finding, the patient was diagnosed with sarcoidosis. Although sarcoidosis rarely involves the thyroid gland, in the present case, thyroid CNB was an alternative diagnostic method that allowed a pathological diagnosis to be obtained.

Keywords: thyroid needle biopsy; thyroid sarcoidosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Biopsy, Needle
  • Female
  • Granuloma / pathology
  • Humans
  • Lung
  • Lymphadenopathy / diagnostic imaging
  • Mediastinum
  • Radiography
  • Radionuclide Imaging
  • Sarcoidosis / diagnostic imaging*
  • Sarcoidosis / pathology
  • Thyroid Diseases / diagnostic imaging*
  • Thyroid Diseases / pathology
  • Thyroid Gland / pathology
  • Tomography, X-Ray Computed
  • Ultrasonography