In Vitro Activities of Gepotidacin (GSK2140944) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas

Ken B Waites; Donna M Crabb; Li Xiao; Lynn B Duffy

doi:10.1128/AAC.01064-17

In Vitro Activities of Gepotidacin (GSK2140944) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas

Antimicrob Agents Chemother. 2017 Sep 22;61(10):e01064-17. doi: 10.1128/AAC.01064-17. Print 2017 Oct.

Authors

Ken B Waites¹, Donna M Crabb², Li Xiao³, Lynn B Duffy²

Affiliations

¹ Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA [email protected].
² Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
³ Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Abstract

Gepotidacin, a novel first-in-class triazaacenaphthylene topoisomerase II inhibitor, was tested against 85 type strains and clinical isolates of Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma parvum, and Ureaplasma urealyticum in comparison to levofloxacin, moxifloxacin, azithromycin or clindamycin, and tetracycline. Gepotidacin MIC₉₀s (μg/ml) were 0.125 (M. pneumoniae), 0.032 (M. genitalium), 2 (M. hominis), and 8 (Ureaplasma species). Gepotidacin activity was not affected by resistance to fluoroquinolones, tetracyclines, or macrolides in the strains tested. Gepotidacin merits further study for treating infections caused by these organisms.

Keywords: antimicrobial resistance; gepotidacin (GSK2140944); mycoplasma; ureaplasma.

MeSH terms

Acenaphthenes / pharmacology*
Anti-Bacterial Agents / pharmacology*
Drug Resistance, Bacterial / physiology
Fluoroquinolones / pharmacology
Heterocyclic Compounds, 3-Ring / pharmacology*
Humans
Macrolides / pharmacology
Microbial Sensitivity Tests
Mycoplasma Infections / drug therapy
Mycoplasma genitalium / drug effects*
Mycoplasma genitalium / isolation & purification
Mycoplasma hominis / drug effects*
Mycoplasma hominis / isolation & purification
Mycoplasma pneumoniae / drug effects*
Mycoplasma pneumoniae / isolation & purification
Tetracyclines / pharmacology
Topoisomerase II Inhibitors / pharmacology*
Ureaplasma / drug effects*
Ureaplasma / isolation & purification
Ureaplasma Infections / drug therapy
Ureaplasma urealyticum / drug effects*
Ureaplasma urealyticum / isolation & purification

Substances

Acenaphthenes
Anti-Bacterial Agents
Fluoroquinolones
Heterocyclic Compounds, 3-Ring
Macrolides
Tetracyclines
Topoisomerase II Inhibitors
gepotidacin