Abstract
Ten new glycosides, 6,10-O-di-trans-feruloyl catalpol (1), 6,6'-O-di-trans-feruloyl catalpol (2), 3,4-dihydro-6-O-di-trans-feruloyl catalpol (10), (8R,7'S,8'R)-lariciresinol 9'-O-β-d-(6-O-trans-feruloyl)glucopyranoside (17), and ovatosides A-F (18-22, 24), were isolated from the stem bark of Catalpa ovata along with 19 known compounds. All isolates, except 6 (catalposide) and 9 (6-O-veratroyl catalpol), were found to scavenge peroxynitrite (ONOO-) formed by 3-morpholinosydnonimine. In particular, 12 compounds showed potent activity, with IC50 values in the range 0.14-2.2 μM.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Bignoniaceae / chemistry*
-
Furans / chemistry*
-
Furans / isolation & purification*
-
Glucosides / chemistry*
-
Glucosides / isolation & purification*
-
Glycosides / chemistry*
-
Glycosides / isolation & purification*
-
Inhibitory Concentration 50
-
Iridoid Glucosides / chemistry*
-
Iridoid Glucosides / isolation & purification*
-
Iridoids / chemistry*
-
Iridoids / isolation & purification*
-
Lignans / chemistry*
-
Lignans / isolation & purification*
-
Molecular Structure
-
Peroxynitrous Acid / chemistry*
-
Peroxynitrous Acid / isolation & purification*
-
Plant Stems
Substances
-
3,4-dihydro-6-O-di-trans-feruloyl catalpol
-
6,10-O-di-trans-feruloyl catalpol
-
6-O-veratroyl catalpol
-
Furans
-
Glucosides
-
Glycosides
-
Iridoid Glucosides
-
Iridoids
-
Lignans
-
Peroxynitrous Acid
-
catalpol
-
lariciresinol
-
catalposide