Short Communication: Mycobacterium avium Complex Infection and Immune Reconstitution Inflammatory Syndrome Remain a Challenge in the Era of Effective Antiretroviral Therapy

Olivia C Smibert; Jason A Trubiano; Gail B Cross; Jennifer F Hoy

doi:10.1089/AID.2017.0030

Short Communication: Mycobacterium avium Complex Infection and Immune Reconstitution Inflammatory Syndrome Remain a Challenge in the Era of Effective Antiretroviral Therapy

AIDS Res Hum Retroviruses. 2017 Dec;33(12):1202-1204. doi: 10.1089/AID.2017.0030. Epub 2017 Sep 6.

Authors

Olivia C Smibert¹, Jason A Trubiano¹, Gail B Cross¹, Jennifer F Hoy¹

Affiliation

¹ Department of Infectious Diseases, Alfred Hospital and Monash University , Melbourne, Victoria, Australia .

PMID: 28791872
DOI: 10.1089/AID.2017.0030

Abstract

A 10-year review of disseminated Mycobacterium avium complex (MAC) infection and MAC-immune reconstitution inflammatory syndrome in HIV-positive patients (2004-2014) at a state-wide tertiary referral HIV service demonstrates that despite advances in antiretroviral therapy, MAC infection remains a therapeutic challenge, particularly intra-abdominal disease.

Keywords: HIV; IRIS; MAC; Mycobacterium avium complex; antiretroviral therapy; immune reconstitution.

MeSH terms

AIDS-Related Opportunistic Infections / drug therapy*
Adult
Anti-HIV Agents / therapeutic use*
Antiretroviral Therapy, Highly Active*
Clarithromycin / therapeutic use
Drug Therapy, Combination
Ethambutol / therapeutic use
Female
HIV Infections / drug therapy*
Humans
Immune Reconstitution Inflammatory Syndrome / drug therapy
Immune Reconstitution Inflammatory Syndrome / pathology*
Male
Middle Aged
Mycobacterium avium Complex / immunology
Mycobacterium avium Complex / pathogenicity
Mycobacterium avium-intracellulare Infection / drug therapy*
Mycobacterium avium-intracellulare Infection / immunology
Mycobacterium avium-intracellulare Infection / pathology*
Rifabutin / therapeutic use

Substances

Anti-HIV Agents
Rifabutin
Ethambutol
Clarithromycin