Three-point linkage analysis employing C3 and 19cen markers assigns the myotonic dystrophy gene to 19q

U Friedrich; H Brunner; D Smeets; E Lambermon; H H Ropers

doi:10.1007/BF00281077

Three-point linkage analysis employing C3 and 19cen markers assigns the myotonic dystrophy gene to 19q

Hum Genet. 1987 Mar;75(3):291-3. doi: 10.1007/BF00281077.

Authors

U Friedrich, H Brunner, D Smeets, E Lambermon, H H Ropers

PMID: 2881880
DOI: 10.1007/BF00281077

Abstract

In seven large families with myotonic dystrophy (DM) comprising 102 individuals, linkage studies were performed employing restriction fragment length polymorphisms in the complement component 3 gene and the 19cen C banding heteromorphism as genetic markers. Three-point linkage analysis excludes DM from the 19cen-C3 segment and strongly supports its assignment to the proximal long arm of chromosome 19.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosomes, Human, Pair 19*
Complement C3 / genetics
Female
Genetic Linkage*
Genetic Markers*
Humans
Male
Myotonic Dystrophy / genetics*
Polymorphism, Restriction Fragment Length

Substances

Complement C3
Genetic Markers