Abstract
During 2013-2016, we isolated blaNDM- and blaVIM-harboring Enterobacteriaceae and nonfermentative bacteria from patients in the Philippines. Of 130 carbapenem-resistant isolates tested, 45 were Carba NP-positive; 43 harbored blaNDM, and 2 harbored blaVIM. Multidrug-resistant microbial pathogen surveillance and antimicrobial drug stewardship are needed to prevent further spread of New Delhi metallo-β-lactamase variants.
Keywords:
Enterobacteriaceae; New Delhi metallo-β-lactamase–producing; antimicrobial resistance; bacteria; carbapenem-resistant; carbapenemase-producing; enteric infections; military treatment facility; multidrug resistance; nonfermentative bacteria; the Philippines.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics*
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Bacterial Proteins / metabolism
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Carbapenem-Resistant Enterobacteriaceae / drug effects
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Carbapenem-Resistant Enterobacteriaceae / genetics*
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Carbapenem-Resistant Enterobacteriaceae / isolation & purification
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Carbapenems / pharmacology
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Enterobacteriaceae Infections / drug therapy
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Enterobacteriaceae Infections / epidemiology*
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Enterobacteriaceae Infections / microbiology
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Gene Expression
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Humans
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Isoenzymes / genetics
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Isoenzymes / metabolism
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Microbial Sensitivity Tests
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Multilocus Sequence Typing
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Philippines / epidemiology
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Plasmids / chemistry
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Plasmids / metabolism*
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Prevalence
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Tertiary Care Centers
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beta-Lactam Resistance / genetics*
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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Isoenzymes
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beta-Lactamases
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carbapenemase