The Effects of Cortical Hypometabolism and Hippocampal Atrophy on Clinical Trajectories in Mild Cognitive Impairment with Suspected Non-Alzheimer's Pathology: A Brief Report

Jun Ku Chung; Eric Plitman; Shinichiro Nakajima; Fernando Caravaggio; Shunichiro Shinagawa; Yusuke Iwata; Philip Gerretsen; Julia Kim; Hiroyoshi Takeuchi; Raihaan Patel; M Mallar Chakravarty; Antonio Strafella; Ariel Graff-Guerrero; Alzheimer’s Disease Neuroimaging Initiative

doi:10.3233/JAD-170098

The Effects of Cortical Hypometabolism and Hippocampal Atrophy on Clinical Trajectories in Mild Cognitive Impairment with Suspected Non-Alzheimer's Pathology: A Brief Report

J Alzheimers Dis. 2017;60(2):341-347. doi: 10.3233/JAD-170098.

Authors

Jun Ku Chung^{1

2}, Eric Plitman^{1

2}, Shinichiro Nakajima^{2

3

4

5}, Fernando Caravaggio^{2

3}, Shunichiro Shinagawa⁶, Yusuke Iwata^{2

4}, Philip Gerretsen^{2

3

5}, Julia Kim^{1

2}, Hiroyoshi Takeuchi^{3

4}, Raihaan Patel^{7

8}, M Mallar Chakravarty^{7

8}, Antonio Strafella^{9

10

11}, Ariel Graff-Guerrero^{1

2

3

4

5}; Alzheimer’s Disease Neuroimaging Initiative

Affiliations

¹ Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
² Multimodal Imaging Group - Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
³ Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
⁴ Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan.
⁵ Geriatric Mental Health Division, Centre for Addiction and Mental Health, Toronto, ON, Canada.
⁶ The Jikei University School of Medicine, Tokyo, Japan.
⁷ Cerebral Imaging Centre, Douglas Mental Health Institute, McGill University, Montreal, QC, Canada.
⁸ Department of Psychiatry and Biomedical Engineering, McGill University, Montreal, QC, Canada.
⁹ Research Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
¹⁰ Division of Brain, Imaging and Behaviour - Systems Neuroscience, Krembil Research Institute, UHN, University of Toronto, Toronto, ON, Canada.
¹¹ Morton and Gloria Shulman Movement Disorder Unit and E.J. Safra Parkinson Disease Program, Neurology Division, Department of Medicine, Toronto Western Hospital, UHN, University of Toronto, Toronto, ON, Canada.

PMID: 28826178
DOI: 10.3233/JAD-170098

Abstract

The clinical and structural trajectories of suspected non-Alzheimer' pathology (SNAP) remain elusive due to its heterogeneous etiology. Baseline and longitudinal clinical (global cognition, daily functioning, symptoms of dementia, and learning memory) and hippocampal volume trajectories over two years were compared between patients with amnestic mild cognitive impairment (aMCI) with SNAP with reduced hippocampal volumes (SNAP+HIPPO) and aMCI patients with SNAP without reduced hippocampal volumes. SNAP+HIPPO showed overall worse baseline cognitive functions. Longitudinally, SNAP+HIPPO showed faster deterioration of clinical symptoms of dementia. Having both hippocampal atrophy and cortical hypometabolism without amyloid pathology may exacerbate symptoms of dementia in aMCI.

Keywords: Functional decline; hippocampus; mild cognitive impairment; suspected non-Alzheimer’s pathology.

MeSH terms

Aged
Aged, 80 and over
Amyloid / metabolism
Atrophy / etiology
Atrophy / pathology
Cerebral Cortex / diagnostic imaging
Cerebral Cortex / metabolism*
Cognitive Dysfunction / complications*
Cognitive Dysfunction / diagnostic imaging
Cognitive Dysfunction / pathology*
Female
Hippocampus / diagnostic imaging
Hippocampus / pathology*
Humans
Longitudinal Studies
Male
Metabolic Diseases / diagnostic imaging
Metabolic Diseases / etiology*
Metabolic Diseases / pathology
Models, Statistical
Positron-Emission Tomography

Substances

Amyloid