Associations of TNFR1 with kidney function outcomes by age, gender, and baseline kidney function status: Data from the Heart and Soul Study

Meyeon Park; Daniela Maristany; Debbie Huang; Michael G Shlipak; Mary Whooley

doi:10.1016/j.dib.2017.07.048

Associations of TNFR1 with kidney function outcomes by age, gender, and baseline kidney function status: Data from the Heart and Soul Study

Data Brief. 2017 Jul 26:14:366-370. doi: 10.1016/j.dib.2017.07.048. eCollection 2017 Oct.

Authors

Meyeon Park^{1

2}, Daniela Maristany³, Debbie Huang¹, Michael G Shlipak^{2

4

5}, Mary Whooley^{2

4

5}

Affiliations

¹ Division of Nephrology, University of California, San Francisco, San Francisco, CA, USA.
² Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
³ School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
⁴ San Francisco VA Medical Center, San Francisco, CA, USA.
⁵ Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.

Abstract

Tumor necrosis factor receptor type 1 (TNFR1) is associated with kidney disease and mortality risk in various populations [1], [2]. We evaluated associations of TNFR1 with mortality and mediators of this relationship in doi: 10.1016/j.atherosclerosis.2017.05.021. Whether or not these associations are influenced by age, gender, or baseline kidney function are not known. We evaluated associations of TNFR1 levels with measures of kidney function stratifying by these variables. Our outcomes included estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m², albumin to creatinine ratio (ACR) >30 mg/g, and rapid kidney function loss, defined as a change in eGFR of greater than 3% per year.

Keywords: Biomarkers; Data; Kidney disease.

Grants and funding

K23 DK099238/DK/NIDDK NIH HHS/United States