B-cell receptor sequencing of anti-citrullinated protein antibody (ACPA) IgG-expressing B cells indicates a selective advantage for the introduction of N-glycosylation sites during somatic hypermutation

Ann Rheum Dis. 2018 Jun;77(6):956-958. doi: 10.1136/annrheumdis-2017-212052. Epub 2017 Aug 23.
No abstract available

Keywords: B cells; ant-ccp; autoantibodies; autoimmunity; rheumatoid arthritis.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis, Rheumatoid / genetics*
  • Autoantibodies / genetics*
  • Autoantigens / immunology
  • B-Lymphocytes / immunology
  • Glycosylation
  • Humans
  • Immunoglobulin G / genetics
  • Peptides, Cyclic / immunology*
  • Receptors, Antigen, B-Cell / genetics*
  • Somatic Hypermutation, Immunoglobulin*

Substances

  • Autoantibodies
  • Autoantigens
  • Immunoglobulin G
  • Peptides, Cyclic
  • Receptors, Antigen, B-Cell
  • cyclic citrullinated peptide