Spatio-temporal study of environmental nontuberculous mycobacteria isolated from Wardha district in Central India

Antonie Van Leeuwenhoek. 2018 Jan;111(1):73-87. doi: 10.1007/s10482-017-0927-2. Epub 2017 Aug 23.

Abstract

During the last two decades, nontuberculous mycobacteria (NTM) have gained in importance but there is still a paucity of data, particularly for environmental isolates. We studied, over a period of two years, the spatio-temporal features of NTM isolates obtained from different environmental sources in Wardha district, India. A total of 1398 samples (699 each of soil and water) were tested and 170 (12.2%) yielded NTM isolates, including 123 from soil and 47 from water samples. Out of 170 NTM isolates, 107 (63%) belonged to potentially pathogenic mycobacteria (PPM) and 63 (37%) to the less pathogenic mycobacterial (LPM) group. Overall, maximum isolation was obtained in rainy season (20.3%) followed by winter (13.5%), post rainy (8.7%) and summer seasons (5.8%). Mycobacterium fortuitum, Mycobacterium gordonae and Mycobacterium avium complex (MAC) were common isolates followed by Mycobacterium flavescens, Mycobacterium scrofulaceum, Mycobacterium simiae and Mycobacterium marinum. From soil, isolation of NTM was highest from grounds used for community gatherings (42.8%) followed by soil from residential premises (27.7%) and near the wells (26.0%). From drinking water sources, highest NTM isolation was obtained from wells (15.4%) followed by treated water tanks (6.9%), household receptacles (6.3%), hand pumps (5.6%) and tap water supply (3.5%). Isolation from natural canal water was 6.6%, while from drainage and waste water ponds isolation was 8.3%. The results of the study revealed that in Wardha district, NTM are present both in the soil and drinking water. As NTM can be pathogenic, particularly in immune-compromised individuals, these can be of potential risk to the human population.

Keywords: Environment; Nontuberculous Mycobacteria; Seasonal variation; Sites; Soil; Speciation; Water.

MeSH terms

  • DNA, Ribosomal Spacer
  • Environmental Microbiology*
  • Humans
  • India
  • Nontuberculous Mycobacteria / classification*
  • Nontuberculous Mycobacteria / genetics
  • Nontuberculous Mycobacteria / isolation & purification
  • Phylogeny
  • RNA, Ribosomal / genetics
  • Soil Microbiology
  • Spatio-Temporal Analysis*
  • Water Microbiology

Substances

  • DNA, Ribosomal Spacer
  • RNA, Ribosomal